Shanghai Xinfan Bio: Zinc blocks the absorption of manganese by Streptococcus pneumoniae, and the bacteria are cleared

Researchers have shown that zinc can "starve" by preventing the uptake of manganese by S. pneumoniae, a finding that paves the way for antibacterials against S. pneumoniae. Streptococcus pneumoniae kills children, the elderly and other susceptible people by causing pneumonia, meningitis and other serious infectious diseases, killing more than 1 million people each year and is the world's deadliest bacteria. Scientists have previously discovered that zinc plays an important role in the body's resistance to bacterial infections. This study is the first to discover how zinc actually blocks an important signaling pathway that causes the bacteria to starve. In the study, the researchers described a transporter of zinc "clogging" bacteria, making it impossible for S. pneumoniae to take up the mechanism of manganese, an important metal needed to invade the body and cause disease. Studies have revealed that this bacterial transporter (PsaBCA) utilizes a "spring-hammer" mechanism to bind metals. The difference in size between the two metals, manganese and zinc, causes this transporter to bind them in different ways. Zinc is relatively small, which means that when it binds to this transporter, this mechanism will overly enclose the zinc, forming an important spring in the protein that prevents it from over-expanding, blocking it, blocking it. The ability of this transporter to take up manganese is broken. This research spans the fields of chemistry, biochemistry, microbiology, and immunology, and observes at the level of atomic detail how this transporter maintains bacterial activity by ingesting an important metal manganese, while also making bacteria susceptible to another The mechanism by which metal zinc kills. The researchers pointed out that without manganese, these bacteria can be easily removed by the immune system. This is the first time scientists have learned about the functional mechanisms of these transporter types. With this new information, researchers can begin designing the next generation of antimicrobials that target and block these important transporters.

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