According to reports, a British journal recently published a medical study showing that diabetes can increase the risk of cancer.
Hyperglycemia has a negative effect on the level of 5-hydroxymethylcytosine (5hmC), and 5hmC is affected by the DNA modification that is affected by cancer.
Diabetes is a group of metabolic diseases characterized by hyperglycemia. Hyperglycemia is caused by defective insulin secretion or impaired biological effects, or both. The long-term high blood sugar in diabetes causes chronic damage and dysfunction of various tissues, especially the eyes, kidneys, heart, blood vessels, and nerves.
According to data, the number of adult diabetic patients worldwide has tripled in the past 40 years.
Researchers have discovered that a tumor suppressor gene TET2 can catalyze the conversion of 5mC into 5hmC, and the decrease in its activity will also reduce the level of 5hmC in cancer patients. AMP activated protein kinase (AMPK), as an important nutrient and energy receptor, can phosphorylate TET2 and increase its stability.
Experiments in mice showed that the hypoglycemic drug metformin can inhibit tumor growth through the AMPK-TET2 pathway, which brings new ideas to the clinic.
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